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Listar por autor "Angulo Álvarez, Jesús"
Mostrando ítems 1-20 de 24
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Artículo
A STD-NMR Study of the Interaction of the Anabaena Ferredoxin-NADP+ Reductase with the Coenzyme
Antonini, Lara V.; Peregrina, José R.; Angulo Álvarez, Jesús; Medina, Milagros; Nieto, Pedro M. (MDPI, 2014)Ferredoxin-NADP+ reductase (FNR) catalyzes the electron transfer from ferredoxin to NADP+ via its flavin FAD cofactor. To ...
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Artículo
Correction: Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design
Beekman, Andrew M.; Cominetti, Marco M. D.; Walpole, Samuel; Prabhu, Saurabh; O'Connell, Maria A.; Angulo Álvarez, Jesús; Searcey, Mark (Royal Society of Chemistry: Open Access, 2019) -
Tesis Doctoral
Estudio de la estructura tridimensional y de la dinámica de oligosacáridos modelos de glicosaminoglicanos mediante RMN y simulaciones de dinámica molecular
Angulo Álvarez, Jesús (2002)En esta Tesis Doctoral se presentan los estudios estructurales mediante espectroscopia de Resonancia Magnética Nuclear y ...
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Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B
Monaco, Serena; Walpole, Samuel; Doukani, Hassan; Nepravishta, Ridvan; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Ramos Soriano, Francisco Javier; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Wiley, 2020)Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...
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Fragment-based screening of the donor substrate specificity of human blood group B galactosyltransferase using saturation transfer difference NMR
Blume, Astrid; Angulo Álvarez, Jesús; Biet, Thorsten; Peters, Hannelore; Benie, Andrew J.; Palcic, Monica; Peters, Thomas (American Society for Biochemistry and Molecular Biology, 2006)Saturation transfer difference NMR experiments on human blood group B α-(1,3)-galactosyltransferase (GTB) for the first ...
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Artículo
Fucosidases from the human gut symbiont Ruminococcus gnavus
Wu, Haiyang; Rebello, Osmond; Owen, C. David; Walpole, Samuel; Bennati Granier, Chloe; Ndeh, Didier; Monaco, Serena; Angulo Álvarez, Jesús (Springer, 2021)The availability and repartition of fucosylated glycans within the gastrointestinal tract contributes to the adaptation ...
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Ginsenosides act as positive modulators of P2X4 receptors
Dhuna, K.; Felgate, M.; Bidula, S.M.; Walpole, Samuel; Bibic, L.; Cromer, B.A.; Angulo Álvarez, Jesús; Sanderson, J.; Stebbing, M.J.; Stokes, L. (American Society for Pharmacology and Experimental Therapeutics (ASPET), 2019)We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allosteric modulators ...
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Artículo
Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design
Beekman, Andrew M.; Cominetti, Marco M. D.; Walpole, Samuel; Prabhu, Saurabh; O'Connell, Maria A.; Angulo Álvarez, Jesús; Searcey, Mark (Royal Society of Chemistry: Open Access, 2019)The development of protein–protein interaction (PPI) inhibitors with therapeutic value is of increasing importance as the ...
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Artículo
Importance of the polarity of the glycosaminoglycan chain on the interaction with FGF-1
Muñoz García, Juan Carlos; García Jiménez, M. José; Carrero, Paula; Canales, Ángeles; Jiménez Barbero, Jesús; Martín Lomas, Manuel; Imberty, Anne; Paz, José L. de; Angulo Álvarez, Jesús; Lortat Jacob, Hughes; Nieto, Pedro M. (Oxford University Press, 2014)Heparin-like saccharides play an essential role in binding to the fibroblast growth factor (FGF)-1 and to their membrane ...
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Tesis Doctoral
Insights on the structure and dynamics of glycosaminoglycans and their interactions with langering: NMR and computational studies
Muñoz García, Juan Carlos (2013-10-25)La determinación de las estructuras tridimensionales de los oligosacáridos así como la comprensión de las bases moleculares ...
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Artículo
Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket
Monaco, Serena; Ramírez Cárdenas, Jonathan; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Multidisciplinary Digital Publishing Institute (MDPI), 2022)In recent years, Saturation Transfer Difference NMR (STD NMR) has been proven to be a powerful and versatile ligand-based ...
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Tesis Doctoral
Interacciones de oligomanósidos con el anticuerpo 2g12 (anti vih-1). Estudios por RMN y modelización molecular
Enriquez Navas, Pedro Miguel (2011-03-23)En esta tesis doctoral, se ha abordado el estudio de las interacciones en disolución entre una serie de oligomanósidos, ...
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Artículo
Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7
Bidula, S.M.; Cromer, B.A.; Walpole, Samuel; Angulo Álvarez, Jesús; Stokes, Leanne (Nature Research (part of Springer Nature): Fully open access journals, 2019)P2X7 receptors are important in the regulation of inflammatory responses and immune responses to intracellular pathogens ...
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Artículo
Molecular Recognition of Natural and Non-Natural Substrates by Cellodextrin Phosphorylase from Ruminiclostridium Thermocellum Investigated by NMR Spectroscopy
Gabrielli, Valeria; Muñoz García, Juan Carlos; Pergolizzi, Giulia; de Andrade, Peterson; Khimyak, Yaroslav Z.; Field, Robert A.; Angulo Álvarez, Jesús (Wiley-Blackwell, 2021)β-1→4-Glucan polysaccharides like cellulose, derivatives and analogues, are attracting attention due to their unique ...
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Artículo
Multifrequency STD NMR Unveils the Interactions of Antibiotics With Burkholderia multivorans Biofilm Exopolysaccharide
Nepravishta, Ridvan; Monaco, Serena; Distefano, Marco; Rizzo, Roberto; Cescutti, Paola; Angulo Álvarez, Jesús (Frontiers Media S.A., 2021)Biofilms confine bacterial cells within self-produced matrices, offering advantages such as protection from antibiotics ...
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Artículo
NleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery
García García, Ana; Hicks, Thomas; El Qaidi, Samir; Zhu, Congrui; Hardwidge, Philip R.; Angulo Álvarez, Jesús; Hurtado Guerrero, Ramón (Royal Society of Chemistry, 2021)NleB/SseK effectors are arginine-GlcNAc-transferases expressed by enteric bacterial pathogens that modify host cell proteins ...
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NMR studies on carbohydrate interactions with DC-SIGN towards a quantitative STD analysis
Guzzi, Cinzia; Muñoz García, Juan Carlos; Enriquez Navas, Pedro Miguel; Rojo, Javier; Angulo Álvarez, Jesús; Nieto, Pedro M. (De Gruyter, 2013)The recent introduction of saturation transfer difference (STD) NMR has increased the tools for the study of protein–carbohydrate ...
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Artículo
Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity
Latorre Muro, Pedro; Baeza, Josue; Hurtado Guerrero, Ramón; Hicks, Thomas; Delso, Ignacio; Hernández Ruiz, Cristina; Velázquez Campoy, Adrián; Lawton, Alexis J.; Angulo Álvarez, Jesús; Denu, John M.; Carrodeguas, José Alberto (American Society for Biochemistry and Molecular Biology Inc., 2021)Acetylation is known to regulate the activity of cytosolic phosphoenolpyruvate carboxykinase (PCK1), a key enzyme in ...
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Artículo
Spatially Resolved STD-NMR Applied to the Study of Solute Transport in Biphasic Systems: Application to Protein-Ligand Interactions
Nepravishta, Ridvan; Monaco, Serena; Muñoz García, Juan Carlos; Khimyak, Yaroslav Z.; Angulo Álvarez, Jesús (SAGE Publications, 2019)Fluid biphasic systems are one of the most interesting dynamic systems in chemistry and biochemistry. In nuclear magnetic ...
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Artículo
Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter
Furze, Christopher M.; Delso, Ignacio; Casal, Enriqueta; Seddon, Chloe; Brown, Chelsea M.; Parker, Hadyn L.; Radhakrishnan, Anjana; Pacheco Gómez, Raul; Stansfeld, Phillip J.; Angulo Álvarez, Jesús; Cameron, Alexander D.; Fullam, Elizabeth (American Society for Biochemistry and Molecular Biology Inc., 2021)The Mycobacterium tuberculosis (Mtb) LpqY-SugABC ATPbinding cassette transporter is a recycling system that imports trehalose ...